For Research Purposes Only. This page summarizes published preclinical and clinical research. It does not constitute medical advice and is not a recommendation for human use.
TB-500
Synthetic fragment of Thymosin Beta-4. Studied for wound healing, muscle and tendon repair, angiogenesis, and anti-inflammatory activity.
- Class
- Thymosin Beta-4 fragment
- Sequence
- LKKTETQ (7 amino acids)
- Trial Status
- Preclinical (fragment)
- Parent Compound
- Phase I/II (Tβ4)
01 · Overview
TB-500 is a synthetic peptide derived from Thymosin Beta-4 (Tβ4), a 43-amino-acid protein present in virtually all nucleated human and animal cells. The TB-500 sequence — LKKTETQ, corresponding to residues 17–23 of Tβ4 — was identified in the 1990s as the actin-binding domain responsible for the majority of Tβ4's biological activity. By isolating this fragment, researchers created a shorter, more accessible compound that retains the key functional properties of the parent protein while being simpler to synthesize.
The central biological role of Tβ4 and its TB-500 fragment is regulation of actin polymerization. Actin filaments are the structural backbone of the cytoskeleton and are essential for cell motility, division, and the migratory response that initiates wound healing. By sequestering globular actin (G-actin) monomers, TB-500 maintains a pool of available actin for rapid filament assembly, facilitating the migration of repair cells — fibroblasts, keratinocytes, and endothelial cells — into injured tissue. This mechanism underpins the angiogenic and anti-inflammatory effects observed across multiple animal models.
RegeneRx Biopharmaceuticals has been the primary clinical developer of full-length Tβ4, conducting Phase I and Phase II trials for acute myocardial infarction (REVEAL trial, NCT01311518) and dry eye syndrome. These trials established a human safety profile for the parent compound, which has informed the broader research interest in TB-500. The isolated TB-500 fragment has not been the subject of formal human clinical trials. Most published research on TB-500 specifically remains in rodent and in vitro models.
Sizes currently sold by tracked vendors: 10.8mg, 100mg, 10MG, 10mg, 15mg, 20mg, 2mg, 30mg, 50mg, 5MG, 5mg.
02 · Research status
Smart et al. (2007, Annals of the New York Academy of Sciences) demonstrated cardiac repair effects of Tβ4 in infarct models. RegeneRx REVEAL trial (Phase II, NCT01311518) investigated Tβ4 in acute MI. Goldstein and Kleinman have published extensively on Tβ4 mechanisms in wound healing models. TB-500 fragment-specific studies appear in Annals of the New York Academy of Sciences and related journals.
03 · Common research protocols
| Loading phase (community-reported) | 2–5mg, twice per week for 4–6 weeks |
| Maintenance phase | 2–5mg once or twice monthly |
| Administration routes studied | Subcutaneous or intramuscular injection |
| Typical vial sizes available | 2mg, 5mg, 10mg |
| Reconstitution solvent | Bacteriostatic water |
| Common stacking | Often combined with BPC-157 (complementary mechanisms; together sold as GLOW or KLOW blends) |
Dose ranges are extrapolated from published animal research and community protocols. No validated human dosing exists for TB-500. This is for educational reference only and is not a recommendation for human use.
Use the reconstitution calculator →04 · Storage & handling
Store lyophilized TB-500 at −20°C. Once reconstituted with bacteriostatic water, store at 4°C and use within 28–30 days. Avoid prolonged exposure to room temperature or direct light.
05 · What to look for when buying
- TB-500 is a moderately complex peptide to synthesize correctly. Independent HPLC purity verification from a third-party lab (such as Finnrick Analytics) is especially important for this compound.
- Verify the compound is sold as TB-500 (the LKKTETQ fragment), not as full-length Thymosin Beta-4. While related, they are different molecules and are priced and dosed differently.
- Quantity accuracy matters: check whether the vendor has been tested for fill accuracy, not just purity. A nominally 5mg vial that contains 3mg of active compound is a significant underperformance.
- TB-500 is frequently sold alongside or in blends with BPC-157 (e.g., GLOW, KLOW stacks). If buying a blend, confirm the stated ratios of each component are independently verified.
- COAs should specify HPLC purity, not just mass spectrometry identity confirmation. Identity confirmation alone does not verify the concentration of active compound.
06 · Price comparison
Prices last checked Oct 26, 2026Lowest listed in-stock price: $23.96 at Swiss Chems (2mg vial, $11.98/mg, shipping unknown)
- 2mg vial$33.99listed price$17.00per mgshipping: unknownIn stockupdated today
- 5mg vial$50.99listed price$10.20per mgshipping: unknownIn stockupdated today
- 10mg vial$85.99listed price$8.60per mgshipping: unknownIn stockupdated today
- 2mg vial$23.96listed price$11.98per mgshipping: unknownIn stockupdated today—No data
- 2mg · 1 unit$29.99listed price$14.99per mgshipping: unknownIn stockupdated today
- 2mg · 1 unit$29.99listed price$14.99per mgshipping: unknownIn stockupdated 1d ago
- 2mg · 1 unit$29.99listed price$14.99per mgshipping: unknownIn stockupdated today
- 10mg · 1 unit$34.99listed price$3.50per mgshipping: unknownIn stockupdated today—No data
- 2mg · 1 unit$37.25listed price$18.63per mgshipping: unknownIn stockupdated today99.0%AVendor
- 5mg · 1 unit$38.00listed price$7.60per mgshipping: unknownIn stockupdated today
- 5mg · 1 unit$39.00listed price$7.80per mgshipping: unknownIn stockstale · 7d old
- 10mg · 1 unit$40.00listed price$4.00per mgshipping: unknownIn stockupdated today
- 10mg · 1 unit$41.60listed price$4.16per mgshipping: unknownIn stockupdated today
- 10mg vial$42.36listed price$4.24per mgshipping: unknownIn stockupdated today—No data
- 10mg · 1 unit$44.99listed price$4.50per mgshipping: unknownIn stockstale · 224d old
- 10mg · 1 unit$44.99listed price$4.50per mgshipping: unknownIn stockupdated today
- 5mg · 1 unit$44.99listed price$9.00per mgshipping: unknownIn stockstale · 224d old
- 5mg · 1 unit$44.99listed price$9.00per mgshipping: unknownIn stockupdated today—No data
- 2mg · 1 unit$45.33listed price$22.66per mgshipping: unknownIn stockstale · 220d old
- 10mg · 1 unit$48.75listed price$4.88per mgshipping: unknownIn stockupdated today
- 5mg · 1 unit$49.99listed price$10.00per mgshipping: unknownIn stockupdated today
- 5mg · 1 unit$49.99listed price$10.00per mgshipping: unknownIn stockupdated today
- 5mg · 1 unit$49.99listed price$10.00per mgshipping: unknownIn stockupdated 1d ago
- 2mg × 10 kits (20mg total)$50.00listed price$2.50per mgshipping: unknownIn stockupdated today
- 5mg · 1 unit$50.99listed price$10.20per mgshipping: unknownIn stockupdated today99.0%AVendor
- 2mg · 1 unit$51.00listed price$25.50per mgshipping: unknownIn stockupdated 1d ago—No data
- 10.8mg · 1 unit$55.00listed price$5.09per mgshipping: unknownIn stockupdated today
- 10mg · 1 unit$57.00listed price$5.70per mgshipping: unknownIn stockupdated today
- 5mg · 1 unit$60.00listed price$12.00per mgshipping: unknownIn stockupdated 1d ago—No data
- 10mg · 1 unit$64.00listed price$6.40per mgshipping: unknownIn stockstale · 28d old
- 10mg · 1 unit$65.00listed price$6.50per mgshipping: unknownIn stockupdated 3d ago
- 10mg · 1 unit$65.00listed price$6.50per mgshipping: unknownIn stockstale · 220d old—No data
- 10mg · 1 unit$65.00listed price$6.50per mgshipping: unknownIn stockstale · 14d old
- 10mg · 1 unit$65.00listed price$6.50per mgshipping: unknownIn stockstale · 220d old
- 5mg vial$67.00listed price$13.40per mgshipping: unknownIn stockupdated today99.0%AVendor
- 2mg · 1 unit$67.00listed price$33.50per mgshipping: unknownIn stockupdated today—No data
- 10mg · 1 unit$68.00listed price$6.80per mgshipping: unknownIn stockupdated today
- 10mg vial$70.00listed price$7.00per mgshipping: unknownIn stockupdated today
- 5mg · 1 unit$72.00listed price$14.40per mgshipping: unknownIn stockupdated today
- 5mg · 1 unit$78.00listed price$15.60per mgshipping: unknownIn stockupdated today
- 2mg × 10 kits (20mg total)$90.00listed price$4.50per mgshipping: unknownIn stockstale · 7d old
- 5mg · 1 unit$92.36listed price$18.47per mgshipping: unknownIn stockstale · 220d old
- 10mg · 1 unit$96.00listed price$9.60per mgshipping: unknownIn stockstale · 220d old
- 5mg × 10 kits (50mg total)$103.00listed price$2.06per mgshipping: unknownIn stockupdated today
- 5mg · 1 unit$105.00listed price$21.00per mgshipping: unknownIn stockupdated today—No data
- 5mg × 10 kits (50mg total)$110.00listed price$2.20per mgshipping: unknownIn stockupdated today
- 10mg · 1 unit$110.00listed price$11.00per mgshipping: unknownIn stockupdated 1d ago—No data
- 5mg × 2 kits (10mg total)$119.99listed price$12.00per mgshipping: unknownIn stockupdated today99.0%AVendor
- 100mg · 1 unit$120.00listed price$1.20per mgshipping: unknownIn stockupdated today
- 10mg · 1 unit$124.00listed price$12.40per mgshipping: unknownIn stockupdated today
- 20mg · 1 unit$130.00listed price$6.50per mgshipping: unknownIn stockupdated 4d ago
- 10mg · 1 unit$136.00listed price$13.60per mgshipping: unknownIn stockupdated today
- 10mg · 1 unit$140.00listed price$14.00per mgshipping: unknownIn stockupdated today
- 10mg · 1 unit$164.97listed price$16.50per mgshipping: unknownIn stockupdated today
- 5mg × 10 kits (50mg total)$165.00listed price$3.30per mgshipping: unknownIn stockstale · 7d old
- 5mg × 3 kits (15mg total)$169.99listed price$11.33per mgshipping: unknownIn stockupdated today99.0%AVendor
- 5mg · 1 unit$177.19listed price$35.44per mgshipping: unknownIn stockstale · 220d old—No data
- 10mg · 1 unit$179.79listed price$17.98per mgshipping: unknownIn stockstale · 220d old
- 10mg × 10 kits (100mg total)$184.00listed price$1.84per mgshipping: unknownIn stockupdated today
- 10mg · 1 unit$184.00listed price$18.40per mgshipping: unknownIn stockupdated today—No data
- 10mg · 1 unit$194.38listed price$19.44per mgshipping: unknownIn stockstale · 220d old—No data
- 10mg × 10 kits (100mg total)$204.00listed price$2.04per mgshipping: unknownIn stockupdated today
- 10mg × 10 kits (100mg total)$251.00listed price$2.51per mgshipping: unknownIn stockupdated today
- 10mg × 10 kits (100mg total)$255.00listed price$2.55per mgshipping: unknownIn stockstale · 7d old
- 2mg × 10 kits (20mg total)$269.55listed price$13.48per mgshipping: unknownIn stockupdated today—No data
- 10mg × 10 kits (100mg total)$279.99listed price$2.80per mgshipping: unknownIn stockupdated today—No data
- 50mg · 1 unit$290.00listed price$5.80per mgshipping: unknownIn stockupdated 4d ago
- 5mg × 6 kits (30mg total)$299.99listed price$10.00per mgshipping: unknownIn stockupdated today99.0%AVendor
- 5mg × 10 kits (50mg total)$351.60listed price$7.03per mgshipping: unknownIn stockupdated today—No data
- 10mg × 10 kits (100mg total)$426.30listed price$4.26per mgshipping: unknownIn stockupdated today—No data
- 10mg × 10 kits (100mg total)$485.00listed price$4.85per mgshipping: unknownIn stockupdated today
- 10mg × 10 kits (100mg total)$486.28listed price$4.86per mgshipping: unknownIn stockupdated today
- 100mg · 1 unit$490.00listed price$4.90per mgshipping: unknownIn stockupdated 4d ago
- 5mg × 10 kits (50mg total)$549.99listed price$11.00per mgshipping: unknownIn stockupdated today99.0%AVendor
- 10mg · 1 unit$56.99listed price$5.70per mgshipping: unknownOut of stockupdated today
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Prices are the listed checkout price for the unit shown — shipping is labeled per offer and unknown unless the vendor publishes terms. Rankings never include paid placement.
40 vendors tracked · prices scraped weekly from vendor sites · open full comparison table →
07 · Third-party purity data
Full data at peptigrity.com ↗Independent HPLC test results — averages across multiple samples.
08 · Frequently asked questions
What is TB-500?
TB-500 is a synthetic peptide derived from Thymosin Beta-4 (Tβ4), a 43-amino-acid protein present in virtually all nucleated human and animal cells. The TB-500 sequence — LKKTETQ, corresponding to residues 17–23 of Tβ4 — was identified in the 1990s as the actin-binding domain responsible for the majority of Tβ4's biological activity.
Is TB-500 FDA approved?
No. The TB-500 fragment is not FDA-approved. Its parent compound, Thymosin Beta-4, was studied in Phase I/II human trials by RegeneRx (cardiac and ocular indications), which established a safety profile for the parent protein — but the fragment itself has no formal human trial data.
Sources: ClinicalTrials.gov — thymosin beta-4 ↗ · PubMed — TB-500 / thymosin beta-4 ↗ · checked Sep 24, 2026
What human trial data exists for TB-500's parent compound?
Full-length Thymosin Beta-4 (not the TB-500 fragment) has been taken into human trials by RegeneRx Biopharmaceuticals — including a Phase II cardiac study registered as NCT01311518. That trial record documents the parent protein's clinical development status; the TB-500 fragment itself has no registered human trial data.
Sources: ClinicalTrials.gov — NCT01311518 ↗ · checked Sep 24, 2026
How much does TB-500 cost?
Across 40 vendors tracked by PepVendors, TB-500 currently runs $1.20–$19.44 per mg at each vendor's best price tier (40 showing in stock). Vial prices and size tiers vary — the live comparison table on this page lists current pricing.
Which vendors have third-party purity data for TB-500?
Independent labs (Finnrick Analytics, Janoshik) have published HPLC purity results for 30 samples of TB-500 or its components: Loti Labs (99.9%), Oasis Labs (99.9%), Core Peptides (99.9%), NextechLabs (99.8%), Injectify (99.8%), Umbrella Labs (99.8%), NUPEPS (99.8%), Biotech Peptides (99.8%), Biolongevity Labs (99.7%), SaiyanMed (99.7%), Simple Peptide (99.6%), Peptidology (99.5%), Hydro Research (99.5%), Royal Peptides (99.5%), Liberty Peptides (99.5%), Coastal Peptides (99.5%), Limitless Life (99.4%), Nexaph (99.4%), Polaris Peptides (99.3%), Prime Peptides (99.3%), Peptide Partners (99.2%), HkRoids (99.2%), Mei Peptide (99.1%), Eternal Peptides (99.0%), Amino Amigos (98.8%), Verified Peptides (98.8%), Paramount Peptides (98.0%), Pure Rawz (97.8%), Reta-Peptide (97.4%), Oupeptide (91.7%). A grade A (≥98%) is the appropriate baseline for research use — check the linked lab reports for batch-level detail and fill-accuracy data.