For Research Purposes Only. This page summarizes published preclinical and clinical research. It does not constitute medical advice and is not a recommendation for human use.
CJC-1295 + Ipamorelin
The most widely researched GH secretagogue stack. CJC-1295 amplifies GHRH signaling; Ipamorelin selectively triggers a clean GH pulse. Complementary mechanisms, commonly used together.
- CJC-1295 Class
- GHRH Analogue (DAC)
- Ipamorelin Class
- Selective GHSR Agonist
- CJC-1295 Trial Phase
- Phase II completed
- Ipamorelin Trial Phase
- Phase II completed
01 · Overview
CJC-1295 and Ipamorelin are paired as a growth hormone secretagogue stack because they stimulate GH release through two distinct, non-overlapping receptor pathways. CJC-1295 is an analogue of growth hormone-releasing hormone (GHRH) and acts at the GHRH receptor on pituitary somatotrophs, increasing the amplitude of GH pulses. Ipamorelin acts at the ghrelin receptor (GHSR-1a), independently triggering GH secretion through a separate signaling pathway. When administered together, they engage both arms of the pituitary GH regulatory axis, producing a synergistic response greater than either compound alone.
CJC-1295 (the DAC version) is modified with a Drug Affinity Complex — a side-chain that enables covalent binding to circulating albumin. This modification dramatically extends the plasma half-life from approximately 30 minutes (seen with Mod GRF 1-29, also called CJC-1295 without DAC) to 6–8 days. A Phase I/II study by Ionescu and Frohman (The Journal of Clinical Endocrinology & Metabolism, 2006) demonstrated dose-dependent, sustained increases in mean GH and IGF-1 concentrations following single injections of CJC-1295 DAC in healthy adults — a notable finding for a research compound. The two variants (with and without DAC) are different compounds with different half-lives, different dosing schedules, and different GH release patterns, and are not interchangeable.
Ipamorelin (originally designated CP-424,391 by Pfizer) is a pentapeptide that binds GHSR-1a with high selectivity. Its defining characteristic relative to older growth hormone-releasing peptides (GHRP-2, GHRP-6, hexarelin) is a highly selective action profile — it stimulates GH release with minimal co-stimulation of ACTH, cortisol, or prolactin. This selectivity makes it the preferred research tool when isolating GH-specific effects. Ipamorelin advanced to Phase II clinical trials for postoperative gastrointestinal ileus (by Helsinn Therapeutics), generating human safety and pharmacokinetic data for the compound, though not for GH-stimulation applications specifically.
Sizes currently sold by tracked vendors: 100mg, 10mg, 12mg, 200mg, 20mg, 2mg, 40mg, 500mg, 50mg, 5mg.
02 · Research status
Ionescu and Frohman (J Clin Endocrinol Metab, 2006): Phase I CJC-1295 data demonstrating sustained GH/IGF-1 elevation over 2 weeks following single injection. Lall et al. characterized ipamorelin's selectivity vs. GHRP-2 and GHRP-6. Svensson et al. published pituitary binding and selectivity data for ipamorelin. Helsinn Phase II trial data for ulimorelin (TZP-101, same compound) are available at clinicaltrials.gov.
03 · Common research protocols
| Typical dose per injection (each peptide) | 100–300 mcg |
| Injection frequency | 1–3 times daily; commonly once before sleep to align with endogenous GH pulse |
| CJC-1295 DAC alternative frequency | Once or twice weekly (due to 6–8 day half-life) |
| Administration route | Subcutaneous injection |
| Typical vial sizes | 2mg, 5mg — sold separately or as blended vials |
| Reconstitution solvent | Bacteriostatic water |
Dose ranges are from published Phase I/II data and community-reported protocols. The CJC-1295 dosing differs substantially between the DAC (long-acting) and no-DAC (short-acting) variants. Confirm which form you have before referencing any protocol. This is for educational reference only and is not a recommendation for human use.
Use the reconstitution calculator →04 · Storage & handling
Store lyophilized peptides at −20°C. Once reconstituted, refrigerate at 4°C and use within 28–30 days. If purchasing as a blend, the stability characteristics of the combined formulation depend on the specific product.
05 · What to look for when buying
- Confirm which CJC-1295 variant you are purchasing: CJC-1295 with DAC (long-acting, ~7-day half-life) vs. CJC-1295 without DAC / Mod GRF 1-29 (short-acting, ~30-minute half-life). These are different compounds with different dosing schedules and are not interchangeable.
- Both CJC-1295 and Ipamorelin are commonly sold as pre-mixed blend vials in addition to being sold separately. Blends are convenient but make it harder to verify the ratio and concentration of each component independently.
- Ipamorelin is a pentapeptide (5 amino acids) and is relatively straightforward to synthesize — purity tends to be higher across vendors compared to more complex peptides. CJC-1295 (with DAC) is more structurally complex due to the DAC modification and warrants closer attention to purity data.
- Finnrick has tested both CJC-1295 and Ipamorelin from multiple vendors. Check purity scores for each compound independently — a vendor may perform well on one and poorly on the other.
- When comparing blended CJC-1295 + Ipamorelin vials, confirm the stated ratio of each peptide and whether the COA covers both components or only one.
06 · Price comparison
Prices last checked Oct 26, 2026| Vendor | Sizes | Price range | Best $/mg | Stock |
|---|---|---|---|---|
| HkRoids | 4 | $44.00 – $189.00 | $0.38 | In stock |
| SaiyanMed | 1 | $115.00 | $1.15 | In stock |
| NUPEPS | 2 | $51.50 – $86.00 | $2.58 | In stock |
| Sunrise BioResearch | 3 | $39.36 – $314.93 | $3.15 | Out of stock |
| Royal Peptides | 4 | $70.00 – $685.00 | $3.42 | In stock |
| Peptidology | 2 | $64.00 – $78.00 | $3.90 | In stock |
| Go Alpha Labs | 2 | $48.99 – $391.99 | $3.92 | In stock |
| Nexaph | 1 | $198.00 | $3.96 | In stock |
| Peptide Partners | 3 | $220.00 – $877.00 | $4.38 | In stock |
| Accelerate Labs | 1 | $50.99 | $5.10 | In stock |
| Eternal Peptides | 1 | $59.99 | $6.00 | In stock |
| Hydro Research | 1 | $60.00 | $6.00 | In stock |
| Coastal Peptides | 1 | $74.00 | $7.40 | In stock |
| Raw AminoVerified | 2 | $87.00 – $92.00 | $7.67 | In stock |
| Core Peptides | 1 | $80.00 | $8.00 | In stock |
| Prime Peptides | 1 | $80.00 | $8.00 | In stock |
| Alpha-Gen | 1 | $84.79 | $8.48 | In stock |
| NextechLabs | 1 | $48.75 | $9.75 | In stock |
| Biolongevity Labs | 1 | $99.97 | $10.00 | In stock |
| Loti Labs | 1 | $74.99 | $15.00 | In stock |
| Steady Meds | 1 | $80.00 | $16.00 | In stock |
| Oasis Labs | 1 | $82.00 | $16.40 | In stock |
| Umbrella LabsVerified | 1 | $89.99 | $18.00 | In stock |
| Pinnacle Peptides | 1 | $54.99 | $27.50 | In stock |
24 vendors tracked · prices scraped weekly from vendor sites · open full comparison table →
07 · Third-party purity data
Full data at finnrick.com ↗Independent HPLC test results — averages across multiple samples.
08 · Frequently asked questions
What is CJC-1295 + Ipamorelin?
CJC-1295 and Ipamorelin are paired as a growth hormone secretagogue stack because they stimulate GH release through two distinct, non-overlapping receptor pathways. CJC-1295 is an analogue of growth hormone-releasing hormone (GHRH) and acts at the GHRH receptor on pituitary somatotrophs, increasing the amplitude of GH pulses.
Is CJC-1295 + Ipamorelin FDA approved?
No — neither component is FDA-approved. Ipamorelin completed Phase II trials (as ulimorelin) for GI motility and CJC-1295 has Phase I/II human data, but neither was approved, and blended vials are research chemicals.
How much does CJC-1295 + Ipamorelin cost?
Across 24 vendors tracked by PepVendors, CJC-1295 + Ipamorelin currently runs $0.38–$27.50 per mg at each vendor's best price tier (23 showing in stock). Vial prices and size tiers vary — the live comparison table on this page lists current pricing.
Which vendors have third-party purity data for CJC-1295 + Ipamorelin?
Independent labs (Finnrick Analytics, Janoshik) have published HPLC purity results for 72 samples of CJC-1295 + Ipamorelin or its components: Loti Labs (100.0%), Prime Peptides (100.0%), Hydro Research (99.9%), Simple Peptide (99.9%), Oasis Labs (99.9%), Pure Tested Peptides (99.9%), Eternal Peptides (99.9%), Prime Peptides (99.9%), Biotech Peptides (99.8%), SaiyanMed (99.8%), Peptide Crafters (99.8%), Royal Peptides (99.8%), HkRoids (99.8%), Polaris Peptides (99.8%), Peptide Partners (99.8%), NextechLabs (99.8%), Biolongevity Labs (99.8%), Biolongevity Labs (99.8%), Go Alpha Labs (99.8%), Polaris Peptides (99.7%), Reta-Peptide (99.7%), Injectify (99.7%), NUPEPS (99.7%), SaiyanMed (99.7%), Peptidology (99.6%), Oupeptide (99.6%), Peptidology (99.6%), Reta-Peptide (99.5%), Peptide Pros (99.5%), NUPEPS (99.5%), Hydro Research (99.5%), Simple Peptide (99.5%), UWA Elite Peptides (99.5%), Core Peptides (99.4%), Royal Peptides (99.4%), Go Alpha Labs (99.4%), Umbrella Labs (99.4%), Coastal Peptides (99.4%), Amino Amigos (99.4%), Peptides 4 Research (99.4%), Nexaph (99.3%), Core Peptides (99.3%), Umbrella Labs (99.2%), Liberty Peptides (99.2%), Peptides 4 Research (99.1%), Alpha-Gen (99.1%), Alpha-Gen (99.0%), Peptide Pros (99.0%), Peptide Sciences (99.0%), NextechLabs (98.8%), Nuscience Peptides (98.8%), Paramount Peptides (98.6%), Verified Peptides (98.6%), Mei Peptide (98.3%), Coastal Peptides (98.2%), Paramount Peptides (97.8%), Verified Peptides (97.4%), Swiss Chems (97.2%), Limitless Life (97.1%), Peptide Partners (97.0%), Pure Rawz (96.2%), Nexaph (95.6%), HkRoids (94.5%), Limitless Life (94.2%), Peptide Crafters (91.9%), Amino Amigos (87.9%), Injectify (87.7%), Liberty Peptides (77.0%), Peptide Sciences (74.8%), Oasis Labs (74.5%), Loti Labs (64.8%), Swiss Chems (55.9%). A grade A (≥98%) is the appropriate baseline for research use — check the linked lab reports for batch-level detail and fill-accuracy data.