For Research Purposes Only. This page summarizes published preclinical and clinical research. It does not constitute medical advice and is not a recommendation for human use.
MOTS-c
Mitochondrial-derived 16-aa peptide encoded in mitochondrial DNA — regulates metabolic homeostasis via AMPK.
01 · What is MOTS-c?
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded in the mitochondrial 12S rRNA gene — unusual because nearly all peptides derive from nuclear DNA. Identified in 2015, it regulates metabolic homeostasis via AMPK activation and has been studied for insulin sensitivity, exercise capacity, and age-related metabolic decline in animal models. Research remains predominantly preclinical.
Sizes currently sold by tracked vendors: 10.61mg, 100mg, 10mg, 15mg, 200mg, 20MG, 20mg, 2mg, 300mg, 400mg, 40mg, 50mg, 80mg.
02 · Price comparison
Prices last checked Oct 26, 2026| Vendor | Sizes | Price range | Best $/mg | Stock |
|---|---|---|---|---|
| UWA Elite Peptides | 2 | $75.00 – $220.00 | $0.55 | In stock |
| SaiyanMed | 3 | $70.00 – $244.00 | $0.61 | In stock |
| HkRoids | 4 | $79.00 – $314.00 | $0.79 | In stock |
| Go Alpha Labs | 4 | $31.49 – $549.49 | $1.37 | In stock |
| Sunrise BioResearch | 3 | $30.78 – $168.31 | $1.68 | Out of stock |
| Royal Peptides | 4 | $60.00 – $675.00 | $1.69 | In stock |
| Nexaph | 1 | $188.00 | $1.88 | In stock |
| Peptide Partners | 6 | $79.00 – $800.00 | $2.00 | In stock |
| NUPEPS | 3 | $33.50 – $91.00 | $2.27 | In stock |
| Umbrella LabsVerified | 2 | $49.99 – $99.99 | $2.50 | In stock |
| Peptidology | 3 | $29.00 – $129.00 | $3.07 | In stock |
| Oasis Labs | 2 | $48.50 – $132.00 | $3.30 | In stock |
| Hydro Research | 1 | $35.00 | $3.50 | In stock |
| Liberty Peptides | 2 | $42.00 – $72.00 | $3.60 | In stock |
| Pure Tested Peptides | 2 | $99.99 – $149.99 | $3.75 | In stock |
| Accelerate Labs | 1 | $37.99 | $3.80 | In stock |
| Peptides 4 Research | 1 | $42.00 | $4.20 | In stock |
| Verified Peptides | 1 | $96.00 | $4.80 | In stock |
| Steady Meds | 4 | $55.00 – $195.00 | $4.88 | In stock |
| Mei Peptide | 2 | $60.00 – $207.00 | $5.17 | In stock |
| Paramount Peptides | 1 | $55.25 | $5.53 | In stock |
| Loti Labs | 1 | $59.99 | $6.00 | In stock |
| Prime Peptides | 1 | $60.00 | $6.00 | In stock |
| NextechLabs | 1 | $64.99 | $6.50 | In stock |
| Reta-Peptide | 1 | $65.00 | $6.50 | In stock |
| Amino Amigos | 1 | $65.00 | $6.50 | In stock |
| Swiss Chems | 2 | $69.95 – $699.50 | $7.00 | In stock |
| Alpha-Gen | 1 | $96.00 | $9.60 | In stock |
| Raw AminoVerified | 1 | $101.00 | $10.10 | In stock |
| Biolongevity Labs | 1 | $109.97 | $11.00 | In stock |
30 vendors tracked · prices scraped weekly from vendor sites · open full comparison table →
03 · Third-party purity data
Full data at peptigrity.com ↗Independent HPLC test results — averages across multiple samples.
04 · Frequently asked questions
What is MOTS-c?
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded in the mitochondrial 12S rRNA gene — unusual because nearly all peptides derive from nuclear DNA. Identified in 2015, it regulates metabolic homeostasis via AMPK activation and has been studied for insulin sensitivity, exercise capacity, and age-related metabolic decline in animal models. Research remains predominantly preclinical.
Is MOTS-c FDA approved?
No. MOTS-c is not FDA-approved and is sold strictly as a research chemical.
How much does MOTS-c cost?
Across 30 vendors tracked by PepVendors, MOTS-c currently runs $0.55–$11.00 per mg at each vendor's best price tier (29 showing in stock). Vial prices and size tiers vary — the live comparison table on this page lists current pricing.
Which vendors have third-party purity data for MOTS-c?
Independent labs (Finnrick Analytics, Janoshik) have published HPLC purity results for 27 samples of MOTS-c or its components: Hydro Research (99.9%), Oasis Labs (99.9%), Peptide Partners (99.8%), NUPEPS (99.8%), SaiyanMed (99.8%), Biolongevity Labs (99.8%), Risynth Bio (99.8%), Polaris Peptides (99.7%), Sunrise BioResearch (99.7%), Injectify (99.6%), Go Alpha Labs (99.6%), Verified Peptides (99.6%), Reta-Peptide (99.5%), Peptidology (99.4%), Royal Peptides (99.4%), Loti Labs (99.4%), HkRoids (99.4%), Simple Peptide (99.4%), Liberty Peptides (99.3%), Eternal Peptides (99.2%), Core Peptides (99.1%), Prime Peptides (99.0%), Umbrella Labs (99.0%), Mei Peptide (98.5%), Nexaph (98.4%), Paramount Peptides (98.0%), Limitless Life (97.5%). A grade A (≥98%) is the appropriate baseline for research use — check the linked lab reports for batch-level detail and fill-accuracy data.